Tanja Schirmeister Selected Research

Cysteine Proteases (Cysteine Protease)

8/2022	New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.
1/2022	Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.
1/2021	Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes.
1/2021	Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2.
1/2021	Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
1/2018	2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.
1/2018	Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates.
1/2018	Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.
1/2017	Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents.
9/2015	Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana.

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Tanja Schirmeister Research Topics

Disease

12	African Trypanosomiasis (Nagana) 08/2022 - 09/2009
8	Neoplasms (Cancer) 01/2022 - 04/2014
6	Infections 01/2021 - 07/2006
5	Malaria 01/2022 - 04/2008
4	Leukemia 02/2022 - 03/2017
3	Parasitic Diseases (Parasitic Disease) 08/2022 - 10/2005
3	Leishmaniasis 01/2018 - 07/2006
3	Multiple Myeloma 10/2016 - 04/2014
3	Severe Acute Respiratory Syndrome 09/2014 - 11/2005
2	Neoplasm Metastasis (Metastasis) 01/2019 - 01/2017
2	Coronavirus Infections 12/2005 - 11/2005
1	Virus Diseases (Viral Diseases) 01/2022
1	COVID-19 01/2022
1	Community-Acquired Infections 01/2020
1	Dengue (Dengue Fever) 12/2019
1	Chagas Disease (American Trypanosomiasis) 01/2018
1	Neglected Diseases 01/2017
1	Melanoma (Melanoma, Malignant) 08/2014
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2014
1	Lymphoma (Lymphomas) 04/2014
1	Hematologic Neoplasms (Hematological Malignancy) 06/2013
1	Rupture 12/2010
1	Falciparum Malaria (Plasmodium falciparum Malaria) 09/2009
1	Autolysis 07/2009
1	Pathologic Processes 01/2006

Drug/Important Bio-Agent (IBA)

13	Cysteine Proteases (Cysteine Protease)IBA 08/2022 - 01/2006
12	rhodesainIBA 08/2022 - 09/2009
12	Pharmaceutical PreparationsIBA 02/2022 - 06/2013
6	EnzymesIBA 01/2022 - 01/2006
5	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 11/2005
5	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2020 - 06/2013
4	falcipain 2IBA 01/2022 - 07/2010
4	PeptidomimeticsIBA 01/2022 - 07/2010
3	Peptides (Polypeptides)IBA 06/2022 - 01/2017
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2006
2	CathepsinsIBA 08/2022 - 09/2015
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2022 - 10/2005
2	Serine Proteases (Serine Protease)IBA 01/2022 - 12/2019
2	Cathepsin LIBA 01/2021 - 01/2017
2	Antiviral Agents (Antivirals)IBA 12/2019 - 09/2014
2	EstersIBA 03/2017 - 07/2010
2	Cathepsin BIBA 01/2017 - 09/2014
1	camostatIBA 01/2022
1	PapainIBA 01/2021
1	Auranofin (Ridaura)FDA Link 09/2020
1	GoldIBA 09/2020
1	MetalsIBA 09/2020
1	SilverIBA 09/2020
1	UbiquitinIBA 09/2020
1	cathepsin SIBA 01/2020
1	Antiparasitic Agents (Antiparasitics)IBA 12/2019
1	KetonesIBA 12/2019
1	SugarsIBA 01/2019
1	Ether (Diethyl Ether)IBA 01/2018
1	benzimidazoleIBA 01/2018
1	cruzipainIBA 01/2018
1	AcidsIBA 03/2017
1	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)IBA 03/2017
1	plakortide EIBA 03/2017
1	carfilzomibIBA 10/2016
1	Dexamethasone (Maxidex)FDA LinkGeneric 10/2016
1	Myeloid-Lymphoid Leukemia ProteinIBA 05/2015
1	human taspase1IBA 05/2015
1	Antineoplastic Agents (Antineoplastics)IBA 08/2014
1	Biological ProductsIBA 08/2014
1	compound FP 2IBA 09/2012
1	aziridine-2,3-dicarboxylateIBA 12/2010
1	DipeptidesIBA 07/2010
1	falcipainIBA 09/2009
1	purineIBA 07/2009
1	Glutamine (L-Glutamine)FDA Link 07/2009
1	pyrimidineIBA 07/2009
1	Interferon-gamma (Interferon, gamma)IBA 07/2006
1	Cysteine Proteinase InhibitorsIBA 07/2006
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2006
1	Aziridines (Ethyleneimines)IBA 10/2005

Therapy/Procedure

4	Therapeutics 01/2022 - 09/2014
2	Drug Therapy (Chemotherapy) 01/2018 - 07/2006
1	Transcutaneous Electric Nerve Stimulation (TENS) 01/2020
1	Immunotherapy 01/2020